Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201923 | 0.81 | CRHR1 (0.42) | CRHR1TLR8TLR7 | |
| SCHEMBL6203740 | 0.81 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL7484320 | 0.81 | CRHR1 (0.50) | CRHR1TLR8TLR7 | |
| SCHEMBL5431282 | 0.80 | CRHR1 (0.69) | CRHR1 | |
| SCHEMBL6202450 | 0.79 | CRHR1 (0.56) | CRHR1TLR7 | |
| SCHEMBL6203258 | 0.76 | CRHR1 (0.47) | CRHR1TLR8TLR7CACNA2D1 | |
| SCHEMBL6203377 | 0.76 | CRHR1 (0.53) | CRHR1TLR7 | |
| SCHEMBL6203769 | 0.75 | CRHR1 (0.39) | CRHR1TLR8TLR7 | |
| SCHEMBL7477663 | 0.75 | CRHR1 (0.45) | CRHR1TLR8TLR7 | |
| SCHEMBL6203035 | 0.74 | CRHR1 (0.51) | CRHR1TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |