Sugi Predict

Sugi Predict / Compounds / SCHEMBL6202482

SCHEMBL6202482

SCHEMBL6202482

CC(=O)Nc1cc(N)c(Cl)cc1F

nearest known ligand 0.46

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 2/20 0.46
▸ CA2 P00918 2/20 0.46
▸ CA9 Q16790 2/20 0.46
▸ HDAC1 Q13547 7/20 0.44
▸ HDAC6 Q9UBN7 1/20 0.44
▸ HDAC3 O15379 2/20 0.41
▸ HDAC2 Q92769 2/20 0.41
▸ NCOR2 Q9Y618 1/20 0.41
▸ NPC1 O15118 2/20 0.41
▸ RAB9A P51151 1/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ PYGL P06737 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7684726 0.86 CA1 (0.46) CA1CA2CA9HDAC1HDAC6
SCHEMBL8610558 0.85 CA1 (0.47) CA1CA2CA9HDAC1HDAC3
SCHEMBL2849268 0.84 GAA (0.38) HDAC1NPC1RAB9AMEN1KMT2A
SCHEMBL2308156 0.84 CA1 (0.50) CA1CA2CA9HDAC1HDAC6
SCHEMBL11069418 0.84 CA1 (0.50) CA1CA2CA9HDAC1HDAC3
SCHEMBL10347961 0.84 HDAC1 (0.47) CA1CA2CA9HDAC1HDAC6
SCHEMBL8777806 0.81 CA1 (0.44) CA1CA2CA9HDAC1HDAC3
SCHEMBL8877907 0.81 CA1 (0.47) CA1CA2CA9HDAC1HDAC6
SCHEMBL31569318 0.80 HDAC1 (0.47) CA1CA2CA9HDAC1HDAC6
SCHEMBL9137511 0.80 CA1 (0.50) CA1CA2CA9HDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973739-B1 N-ARYLSULFONAMIDE- AND PYRROLIDINECARBOXYLIC ACID INTERMEDIATES, AND THEIR USE FOR THE PREPARATION OF HERBICIDAL 1,3-DIOXO-1H-PYRROLO[1,2-C]IMIDAZOLE DERIVATIVES DEGUSSA (DE) 2005-11-02 — — EP disclosed
US-6664400-B2 1-((4-halo-3-sulfonamidophenyl)aminocarbonyl),2-carboxy -pyrrolidine intermediate of given formula DEGUSSA AG (DE) 2003-12-16 — — US disclosed
EP-0862571-B1 HERBICIDAL SULFONAMIDES DEGUSSA (DE) 2003-01-15 — — EP disclosed
US-20020137946-A1 N-arylsulfonamide and pyrrolidinecarboxylic acid intermediates, and their use for the preparation of herbicidal 1,3-dioxo-1h-pyrrolo[1,2-c]imidazole derivatives DEGUSSA AG (DE) 2002-09-26 — — US disclosed
US-6384234-B1 HALOGENATION DEGUSSA AG (DE) 2002-05-07 — — US disclosed
US-6060432-A SYNERGISTIC MIXTURE; CROPS, AGRICULTURE E. I. DU PONT DE NEMOURS AND COMPANY (US) 2000-05-09 — — US disclosed
EP-0973739-A1 N-ARYLSULFONAMIDE- AND PYRROLIDINECARBOXYLIC ACID INTERMEDIATES, AND THEIR USE FOR THE PREPARATION OF HERBICIDAL 1,3-DIOXO-1H-PYRROLO[1,2-C]IMIDAZOLE DERIVATIVES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-01-26 — — EP disclosed
US-5872253-A MULTISTAGE PROCESS WITH REACTION OF ISOTHIOCYANATE WITH AMINE AND CYCLIZATION THE THIOUREA WITH HALOCARBONYL HALIDE AMERICAN CYANAMID COMPANY (US) 1999-02-16 — — US disclosed
EP-0863142-A1 Heterocyclic herbicides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-09-09 — — EP disclosed
EP-0862571-A1 HERBICIDAL SULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1998-09-09 — — EP disclosed
US-4818275-A PREEMERGENCE FMC CORPORATION (US) 1989-04-04 — — US disclosed
US-4801408-A 3-AMINO-4-FLUORO-6-HALOPHENYLTHIOACETIC ACIDS, 5-SUBSTITUTED ACETANILIDES, HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1989-01-31 — — US disclosed
EP-0126419-B1 2-SUBSTITUTED PHENYL-4,5,6,7-TETRAHYDRO-2H-ISOINDOLE-1,3-DIONES, AND THEIR PRODUCTION AND USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1988-08-17 — — EP disclosed
EP-0252982-A4 HERBICIDAL 1-ARYL-4-SUSTITUTTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. FMC CORP (US) 1988-08-17 — — EP disclosed
EP-0252982-A1 HERBICIDAL 1-ARYL-4-SUSTITUTTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC Corporation (US) 1988-01-20 — — EP disclosed
US-4709049-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-11-24 — — US disclosed
US-4684397-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-08-04 — — US disclosed
CN-86108880-A 1-aryl-4 substituting group-1,4-dihydro-5H-tetrazolium-5-ketone and sulfur analogs weedicide thereof — 1987-07-22 — — CN disclosed
WO-1987003873-A1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC CORPORATION (US) 1987-07-02 — — WO disclosed
EP-0126419-A1 2-Substituted phenyl-4,5,6,7-tetrahydro-2H-isoindole-1,3-diones, and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-11-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020137946-A1 N-arylsulfonamide and pyrrolidinecarboxylic acid intermediates, and their use for the preparation of herbicidal 1,3-dioxo-1h-pyrrolo[1,2-c]imidazole derivatives CBR3, CBR1, CLIC1 CA1 1009/4885CA2 41/4885CA9 467/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.