Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.40 |
| ▸ | CDK2 | P24941 | 7/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 6/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203167 | 0.85 | CCNE1 (0.41) | CDK5CDK1PRUNE1CCNE1CDK2 | |
| SCHEMBL6203247 | 0.84 | CCNE2 (0.43) | CCNE1CDK2CCNE2CYP3A4MAPK1 | |
| SCHEMBL6202760 | 0.84 | CDK1 (0.40) | CDK5CDK1PRUNE1CCNE1CDK2 | |
| SCHEMBL6205602 | 0.83 | PARP1 (0.37) | PRUNE1CCNE1CDK2CCNE2PDE4A | |
| SCHEMBL7013189 | 0.82 | CDK1 (0.42) | CDK5CDK1PRUNE1CCNE1CDK2 | |
| SCHEMBL6204126 | 0.80 | SLC29A1 (0.32) | PRUNE1SLC29A1 | |
| SCHEMBL6204808 | 0.78 | PRUNE1 (0.37) | CDK5CDK1PRUNE1CCNE1CDK2 | |
| SCHEMBL6203494 | 0.78 | PRUNE1 (0.40) | CDK5CDK1PRUNE1CCNE1CDK2 | |
| SCHEMBL6204714 | 0.78 | SLC29A1 (0.32) | PRUNE1SLC29A1 | |
| SCHEMBL6205408 | 0.76 | PRUNE1 (0.35) | CDK1PRUNE1MEN1KMT2ASLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | disclosed |