Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 9/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.34 |
| ▸ | CDK2 | P24941 | 9/20 | 0.34 |
| ▸ | PDE5A | O76074 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203495 | 0.86 | PRUNE1 (0.35) | PRUNE1CCNE2CCNE1CDK2PDE5A | |
| SCHEMBL6205408 | 0.83 | PRUNE1 (0.35) | PRUNE1CDK1CCNB1SLC29A1 | |
| SCHEMBL6204808 | 0.79 | PRUNE1 (0.37) | PRUNE1CCNE2CCNE1CDK2PDE5A | |
| SCHEMBL6204714 | 0.79 | SLC29A1 (0.32) | PRUNE1SLC29A1 | |
| SCHEMBL6202754 | 0.78 | CDK5 (0.43) | PRUNE1CCNE2CCNE1CDK2PDE4D | |
| SCHEMBL6204186 | 0.75 | PDE5A (0.36) | PRUNE1CCNE2CCNE1CDK2PDE5A | |
| SCHEMBL3445842 | 0.75 | CDK2 (0.43) | CCNE2CCNE1CDK2CCNT1CDK1 | |
| SCHEMBL6204126 | 0.75 | SLC29A1 (0.32) | PRUNE1SLC29A1 | |
| SCHEMBL6205602 | 0.75 | PARP1 (0.37) | PRUNE1CCNE2CCNE1CDK2PDE4D | |
| SCHEMBL6203167 | 0.74 | CCNE1 (0.41) | PRUNE1CCNE2CCNE1CDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | disclosed |