Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205167 | 0.85 | PPARG (0.43) | PNMTIDO1TAAR1ALDH1A1SLC6A2 | |
| SCHEMBL6204367 | 0.79 | AKR1B1 (0.39) | TAAR1KDM4EALDH1A1POLBSLC6A2 | |
| SCHEMBL5805934 | 0.79 | PNMT (0.52) | PNMTIDO1TAAR1KDM4EALDH1A1 | |
| SCHEMBL18567935 | 0.79 | PNMT (0.52) | PNMTIDO1TAAR1KDM4EALDH1A1 | |
| SCHEMBL6202920 | 0.79 | PNMT (0.47) | PNMTIDO1TAAR1KDM4EALDH1A1 | |
| SCHEMBL3885817 | 0.76 | PNMT (0.57) | PNMTIDO1TAAR1ALDH1A1SLC6A2 | |
| SCHEMBL13692532 | 0.76 | PNMT (0.57) | PNMTIDO1TAAR1ALDH1A1SLC6A2 | |
| SCHEMBL5018770 | 0.75 | PNMT (0.56) | PNMTIDO1TAAR1KDM4EALDH1A1 | |
| SCHEMBL15067430 | 0.74 | PNMT (0.50) | PNMTIDO1TAAR1KDM4EALDH1A1 | |
| SCHEMBL10325760 | 0.74 | PNMT (0.50) | PNMTIDO1TAAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |