Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202922 | 0.79 | PNMT (0.47) | SMN1; SMN2TAAR1POLBALDH1A1KDM4E | |
| SCHEMBL8151995 | 0.79 | TAAR1 (0.40) | AKR1B1SMN1; SMN2TAAR1POLBALDH1A1 | |
| SCHEMBL6205167 | 0.78 | PPARG (0.43) | TAAR1ALDH1A1L3MBTL1SLC6A2SLC6A4 | |
| SCHEMBL15083012 | 0.77 | AKR1B1 (0.43) | AKR1B1SMN1; SMN2TAAR1POLBALDH1A1 | |
| SCHEMBL2426412 | 0.77 | AKR1B1 (0.43) | AKR1B1SMN1; SMN2TAAR1POLBALDH1A1 | |
| SCHEMBL6204365 | 0.76 | AKR1B1 (0.39) | AKR1B1SMN1; SMN2TAAR1POLBALDH1A1 | |
| SCHEMBL6203911 | 0.76 | SMN1; SMN2 (0.36) | SMN1; SMN2TAAR1ALDH1A1GAAKDM4E | |
| SCHEMBL8790684 | 0.72 | TAAR1 (0.46) | AKR1B1SMN1; SMN2TAAR1ALDH1A1MAPT | |
| SCHEMBL6203638 | 0.72 | PNMT (0.58) | TAAR1 | |
| SCHEMBL5018858 | 0.72 | TAAR1 (0.44) | AKR1B1SMN1; SMN2TAAR1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |