Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205165 | 0.85 | PPARG (0.43) | PNMTIDO1TAAR1SLC6A2SLC6A4 | |
| SCHEMBL6204365 | 0.79 | AKR1B1 (0.39) | TAAR1SLC6A2SLC6A4ALDH1A1KDM4E | |
| SCHEMBL6202922 | 0.79 | PNMT (0.47) | PNMTIDO1TAAR1SLC6A2SLC6A4 | |
| SCHEMBL11354697 | 0.76 | ALDH1A1 (0.42) | PNMTIDO1TAAR1ALDH1A1KDM4E | |
| SCHEMBL5018770 | 0.75 | PNMT (0.56) | PNMTIDO1TAAR1SLC6A2SLC6A4 | |
| SCHEMBL8076310 | 0.73 | PNMT (0.48) | PNMTIDO1TAAR1SLC6A2SLC6A4 | |
| SCHEMBL91279 | 0.72 | PNMT (0.62) | PNMTIDO1TAAR1ALDH1A1KDM4E | |
| SCHEMBL6205184 | 0.72 | LMNA (0.43) | IDO1TAAR1SLC6A2SLC6A4ALDH1A1 | |
| SCHEMBL3885817 | 0.72 | PNMT (0.57) | PNMTIDO1TAAR1SLC6A2SLC6A4 | |
| SCHEMBL18567935 | 0.72 | PNMT (0.52) | PNMTIDO1TAAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |