Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202922 | 0.85 | PNMT (0.47) | IDO1PNMTSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6204367 | 0.78 | AKR1B1 (0.39) | SLC6A2SLC6A4SLC6A3TAAR1ALDH1A1 | |
| SCHEMBL6205188 | 0.78 | LMNA (0.43) | PPARGPPARASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6204800 | 0.78 | ALOX15 (0.38) | IDO1SLC6A2SLC6A4LMNAALDH1A1 | |
| SCHEMBL14520626 | 0.78 | SLC6A2 (0.50) | PPARGPPARAIDO1PNMTSLC6A2 | |
| SCHEMBL29679143 | 0.78 | SLC6A2 (0.50) | PPARGPPARAIDO1PNMTSLC6A2 | |
| SCHEMBL16534760 | 0.78 | SLC6A2 (0.50) | PPARGPPARAIDO1PNMTSLC6A2 | |
| SCHEMBL2423546 | 0.78 | SLC6A2 (0.50) | PPARGPPARAIDO1PNMTSLC6A2 | |
| SCHEMBL4298644 | 0.77 | IDO1 (0.50) | PPARGPPARAIDO1PNMTSLC6A2 | |
| SCHEMBL9480324 | 0.77 | IDO1 (0.50) | PPARGPPARAIDO1PNMTSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |