Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6181437 | 0.78 | NOS1 (0.55) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL8064332 | 0.78 | NOS1 (0.58) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL84390 | 0.78 | MAPT (0.60) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL14769932 | 0.77 | METAP2 (0.50) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL12961269 | 0.76 | MAPT (0.49) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL18559548 | 0.75 | MAPT (0.55) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL3722916 | 0.75 | MAPT (0.54) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL21510145 | 0.75 | MAPT (0.50) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL18737272 | 0.75 | MAPT (0.50) | NOS1DYRK1AMETAP2MAPTCYP3A4 | |
| SCHEMBL14534860 | 0.73 | MAPT (0.49) | NOS1DYRK1AMETAP2MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1668601-A | N-substituted tricyclic 3-aminopyrazoles as PDFG receptor inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2005-09-14 | — | — | CN | disclosed |
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |