Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | PDXK | O00764 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203090 | 0.81 | KDM4E (0.31) | KDM4E | |
| SCHEMBL6219173 | 0.81 | AURKA (0.34) | KDM4E | |
| SCHEMBL6204668 | 0.81 | PDXK (0.37) | KDM4EPDXK | |
| SCHEMBL6206164 | 0.78 | PDXK (0.35) | PDXK | |
| SCHEMBL30135451 | 0.76 | JUN (0.33) | — | |
| SCHEMBL791580 | 0.76 | KCNH2 (0.36) | KDM4E | |
| SCHEMBL7966254 | 0.76 | KDM4E (0.32) | KDM4ECSNK1A1CLK4PDXK | |
| SCHEMBL4579208 | 0.76 | NOS3 (0.36) | KDM4ECSNK1A1CLK4PDXK | |
| SCHEMBL30238970 | 0.76 | NOS3 (0.36) | KDM4ECSNK1A1CLK4PDXK | |
| SCHEMBL15942981 | 0.76 | ALDH1A1 (0.33) | KDM4ECSNK1A1CLK4PDXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1560829-A1 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY (II) | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| EP-1560832-A1 | PYRIMIDO 4,5-D PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004041822-A1 | PYRIMIDO[4,5-D]PYRIMIDINE DERIVATIVES WITH ANTICANCER ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |
| WO-2004041821-A1 | PYRIMIDO COMPOUNDS HAVING ANTIPROLIFERATIVE ACTIVITY (II) | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-21 | — | — | WO | disclosed |
| WO-2003009852-A1 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2003-02-06 | — | — | WO | disclosed |