Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 19/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GGT1 | P19440 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3984466 | 0.82 | SLC6A9 (0.54) | PTGS2 | |
| SCHEMBL5355341 | 0.82 | PTGS2 (0.64) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL11006467 | 0.79 | PTGS2 (0.48) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL6203753 | 0.77 | PTGS2 (0.51) | PTGS2ALDH1A1PTGS1HSD17B10 | |
| SCHEMBL942835 | 0.75 | PTGS2 (0.64) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL6906339 | 0.74 | CA12 (0.55) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL30548745 | 0.74 | MAP2K2 (0.48) | ALDH1A1HSD17B10TDP1 | |
| SCHEMBL6655282 | 0.73 | PTGS2 (0.57) | PTGS2 | |
| SCHEMBL6031819 | 0.73 | PTGS2 (0.62) | PTGS2KDM4EALDH1A1ESR1ITGB3 | |
| SCHEMBL6203144 | 0.73 | GAA (0.53) | PTGS2KDM4EALDH1A1ESR1ITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492795-A1 | 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003084961-A1 | 1- OR 3-THIA-BENZONAPHTHOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2003-10-16 | — | — | WO | disclosed |