Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | IL1RN | P18510 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25490049 | 0.95 | HPGD (0.56) | HPGDTSHRL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL12576431 | 0.80 | POLB (0.50) | HPGDTSHRKMT2AALDH1A1MAPT | |
| SCHEMBL14452167 | 0.79 | MEN1 (0.61) | L3MBTL1KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL1266470 | 0.79 | AKR1C3 (0.56) | L3MBTL1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL10898262 | 0.75 | KMT2A (0.50) | KMT2AMEN1 | |
| SCHEMBL1516246 | 0.73 | MAPK1 (0.58) | HPGDTSHRL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL137832 | 0.71 | MAPK1 (0.56) | HPGDTSHRL3MBTL1KMT2AALDH1A1 | |
| SCHEMBL6203436 | 0.71 | ATM (0.46) | L3MBTL1KMT2AALDH1A1MAPTMAPK1 | |
| SCHEMBL1266219 | 0.70 | HSD11B1 (0.54) | HPGDTSHRKMT2AALDH1A1MAPT | |
| SCHEMBL6202187 | 0.70 | MAPT (0.53) | L3MBTL1KMT2AALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250444-B2 | Pyrrole-based HMG-CoA reductase inhibitors | PFIZER INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250444-B2 | Pyrrole-based HMG-CoA reductase inhibitors | PFIZER INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250444-B2 | Pyrrole-based HMG-CoA reductase inhibitors | PFIZER INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-20060287378-A1 | Novel pyrroles and imidazoles | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| US-20050043364-A1 | Novel pyrrole-based HMG-CoA reductase inhibitors | KENNEDY ROBERT MICHAEL (US) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043364-A1 | Novel pyrrole-based HMG-CoA reductase inhibitors | HMGCR, DHCR7, HSD17B12 | HPGD 69/4885TSHR 4025/4885L3MBTL1 4129/4885 |
| US-20060287378-A1 | Novel pyrroles and imidazoles | PPIP5K2, PPIE, PPOX | HPGD 150/4885TSHR 2795/4885L3MBTL1 4821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.