Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTSR1 | P30989 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.48 |
| ▸ | PPARA | Q07869 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203944 | 0.88 | EPHX1 (0.65) | EPHX1PTPN1L3MBTL1MDM2LMNA | |
| SCHEMBL30466138 | 0.82 | NTSR1 (0.58) | NTSR1MAPTL3MBTL1LMNAHSD17B10 | |
| SCHEMBL3370947 | 0.81 | EPHX1 (0.56) | EPHX1PPARGPPARA | |
| SCHEMBL605909 | 0.81 | P4HTM (0.56) | EPHX1MAPTL3MBTL1PPARGPPARA | |
| SCHEMBL6203529 | 0.81 | TSHR (0.52) | PTPN1MAPTLMNAGAA | |
| SCHEMBL22394830 | 0.80 | EPHX1 (0.54) | EPHX1PPARGPPARA | |
| SCHEMBL6201072 | 0.80 | TSHR (0.48) | PTPN1MAPTLMNA | |
| SCHEMBL11733805 | 0.79 | POLB (0.60) | NTSR1MAPTL3MBTL1LMNAHSD17B10 | |
| SCHEMBL29240046 | 0.79 | PTPN1 (0.59) | EPHX1PTPN1MDM2LMNAHSD17B10 | |
| SCHEMBL11520271 | 0.79 | POLB (0.60) | NTSR1MAPTL3MBTL1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| CN-1681763-A | Chemical compounds | ASTRAZENECA AB (SE) | 2005-10-12 | — | — | CN | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |