Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.43 |
| ▸ | HTR3B | O95264 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6205217 | 0.81 | IDO1 (0.39) | PNMTTSHRRECQLIDO1HTR3E | |
| SCHEMBL6205347 | 0.80 | IDO1 (0.47) | IDO1TAAR1MAOB | |
| SCHEMBL2427261 | 0.79 | PNMT (0.69) | PNMTTSHRRECQLCYP3A4IDO1 | |
| SCHEMBL4294493 | 0.79 | PNMT (0.68) | PNMTTSHRRECQLCYP3A4IDO1 | |
| SCHEMBL6204552 | 0.79 | TAAR1 (0.64) | TSHRIDO1AGXTTAAR1CHRM2 | |
| SCHEMBL6203635 | 0.79 | PNMT (0.58) | PNMTTSHRRECQLCYP3A4IDO1 | |
| SCHEMBL15752667 | 0.79 | IDO1 (0.46) | IDO1AGXTTAAR1MAOAMAOB | |
| SCHEMBL6204388 | 0.79 | SLC1A1 (0.46) | IDO1AGXTTAAR1MAOAMAOB | |
| SCHEMBL10651111 | 0.77 | PNMT (0.60) | PNMTTSHRRECQLCYP3A4IDO1 | |
| SCHEMBL23933856 | 0.77 | PPARA (0.54) | PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |