Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28050756 | 0.80 | TAAR1 (0.50) | IDO1TAAR1ALDH1A1CYP2D6POLB | |
| SCHEMBL15752667 | 0.80 | IDO1 (0.46) | IDO1TAAR1CYP2D6MAOB | |
| SCHEMBL6204552 | 0.80 | TAAR1 (0.64) | IDO1TAAR1 | |
| SCHEMBL6203638 | 0.80 | PNMT (0.58) | IDO1TAAR1MAOB | |
| SCHEMBL6204388 | 0.80 | SLC1A1 (0.46) | IDO1TAAR1MAOB | |
| SCHEMBL14997302 | 0.79 | TAAR1 (0.48) | IDO1TAAR1ALDH1A1CYP2D6POLB | |
| SCHEMBL8257853 | 0.79 | TAAR1 (0.48) | IDO1TAAR1ALDH1A1CYP2D6POLB | |
| SCHEMBL7268862 | 0.78 | LAP3 (0.50) | TAAR1CYP2D6 | |
| SCHEMBL1279581 | 0.78 | LAP3 (0.50) | TAAR1CYP2D6 | |
| SCHEMBL6205345 | 0.78 | IDO1 (0.47) | IDO1TAAR1ALDH1A1CYP2D6MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |