Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203669 | 0.83 | CRHR1 (0.56) | CRHR1 | |
| SCHEMBL5432964 | 0.81 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL6203742 | 0.81 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6204414 | 0.80 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL7482091 | 0.77 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL7480028 | 0.76 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL7474501 | 0.75 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL7478531 | 0.74 | TLR8 (0.44) | CRHR1 | |
| SCHEMBL6201091 | 0.74 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL6200122 | 0.74 | CRHR1 (0.47) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |