Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.39 |
| ▸ | DNM2 | P50570 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202560 | 0.91 | CRHR1 (0.42) | CRHR1DNM2TLR7TLR8 | |
| SCHEMBL5446041 | 0.81 | CRHR1 (0.60) | CRHR1 | |
| SCHEMBL7478779 | 0.78 | CRHR1 (0.44) | CRHR1TLR7TLR8 | |
| SCHEMBL6201923 | 0.76 | CRHR1 (0.42) | CRHR1TLR7TLR8 | |
| SCHEMBL6203035 | 0.76 | CRHR1 (0.51) | CRHR1TLR7TLR8 | |
| SCHEMBL6205812 | 0.75 | CRHR1 (0.45) | CRHR1TLR7TLR8 | |
| SCHEMBL7474850 | 0.75 | CRHR1 (0.46) | CRHR1TLR7TLR8 | |
| SCHEMBL7477663 | 0.74 | CRHR1 (0.45) | CRHR1TLR7TLR8 | |
| SCHEMBL6203258 | 0.73 | CRHR1 (0.47) | CRHR1TLR7TLR8 | |
| SCHEMBL7482439 | 0.73 | CRHR1 (0.53) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | claimed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | claimed |