SCHEMBL6203872

SCHEMBL6203872

CC(C)N(CCO)c1nc(Nc2ccc(Cl)c(C(=O)O)c2)c2c(n1)N(C(C)C)NN2C(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 3/20 0.44
CDK5 Q00535 3/20 0.44
CDK5R1 Q15078 3/20 0.44
CCNE2 O96020 4/20 0.38
CCNE1 P24864 4/20 0.38
CDK2 P24941 4/20 0.38
KDM4E B2RXH2 2/20 0.38
CCNB2 O95067 1/20 0.38
ALDH1A1 P00352 1/20 0.38
NTRK1 P04629 1/20 0.38
INSR P06213 1/20 0.38
CCNB1 P14635 1/20 0.38
PRKACA P17612 1/20 0.38
CCNA2 P20248 1/20 0.38
PRKACG P22612 1/20 0.38
PRKACB P22694 1/20 0.38
MAPK3 P27361 1/20 0.38
CCNA1 P78396 1/20 0.38
NTRK2 Q16620 1/20 0.38
CCNB3 Q8WWL7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6205009 0.93 CDK5 (0.44) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6202658 0.91 CDK1 (0.44) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6205532 0.87 CDK5 (0.35) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6202790 0.85 CDK5 (0.35) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6203387 0.85 CCNE2 (0.38) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6206176 0.83 CDK5 (0.49) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6202083 0.81 CCNE2 (0.48) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL3444266 0.80 CDK5 (0.63) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6204662 0.80 CLK1 (0.41) CDK1CDK5CDK5R1CCNE2CCNE1
SCHEMBL6203210 0.79 CCNE2 (0.42) CDK1CDK5CDK5R1CCNE2CCNE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1539760-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2005-06-15 EP claimed
WO-2004018473-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2004-03-04 WO claimed
EP-1539760-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2005-06-15 EP disclosed
WO-2004018473-A2 AZAPURINE DERIVATIVES INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) 2004-03-04 WO disclosed