Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 5/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 8/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201113 | 0.82 | CDK1 (0.46) | CDK1CDK5CCNE2CCNE1CDK2 | |
| SCHEMBL3444121 | 0.81 | LMNA (0.43) | LMNAHPGDSMN1; SMN2CDK1CDK5 | |
| SCHEMBL3444290 | 0.79 | CDK5 (0.42) | LMNAHPGDSMN1; SMN2CDK1CDK5 | |
| SCHEMBL6203387 | 0.77 | CCNE2 (0.38) | CDK1CDK5CCNE2CCNE1CDK2 | |
| SCHEMBL6202083 | 0.77 | CCNE2 (0.48) | CDK1CDK5CCNE2CCNE1CDK2 | |
| SCHEMBL6016497 | 0.76 | CDK2 (0.59) | CDK1CDK5CCNE2CCNE1CDK2 | |
| SCHEMBL6016661 | 0.76 | CDK2 (0.59) | CDK1CDK5CCNE2CCNE1CDK2 | |
| SCHEMBL6206176 | 0.76 | CDK5 (0.49) | HPGDCDK1CDK5CCNE2CCNE1 | |
| SCHEMBL6203858 | 0.74 | LMNA (0.35) | LMNAHPGDSMN1; SMN2CDK1CDK5 | |
| SCHEMBL6202790 | 0.74 | CDK5 (0.35) | CDK1CDK5CCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | disclosed |