Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424621 | 0.79 | PNMT (0.66) | PNMTTSHRIDO1TAAR1SIGMAR1 | |
| SCHEMBL26004833 | 0.78 | PNMT (0.64) | PNMTTSHRIDO1TAAR1SMN1; SMN2 | |
| SCHEMBL6203919 | 0.78 | PNMT (0.55) | PNMTTSHRIDO1TAAR1TACR1 | |
| SCHEMBL6203638 | 0.76 | PNMT (0.58) | PNMTTSHRIDO1TAAR1APEX1 | |
| SCHEMBL6006682 | 0.76 | PPARA (0.56) | PNMTTSHRTACR1SMN1; SMN2 | |
| SCHEMBL18039209 | 0.76 | TSHR (0.55) | PNMTTSHRTACR1SMN1; SMN2SIGMAR1 | |
| SCHEMBL6204804 | 0.76 | PSMB5 (0.38) | SMN1; SMN2ALOX15MEN1KMT2ANPC1 | |
| SCHEMBL14402442 | 0.76 | PNMT (0.56) | PNMTTSHRIDO1TAAR1SMN1; SMN2 | |
| SCHEMBL6205217 | 0.75 | IDO1 (0.39) | PNMTTSHRIDO1TACR1 | |
| SCHEMBL4629099 | 0.75 | PNMT (0.66) | PNMTTSHRIDO1TAAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |