Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27606231 | 0.86 | PNMT (0.40) | PNMTTSHRSMN1; SMN2TACR1MEN1 | |
| SCHEMBL6203922 | 0.78 | PNMT (0.55) | PNMTTSHRIDO1SMN1; SMN2TAAR1 | |
| SCHEMBL6203635 | 0.76 | PNMT (0.58) | PNMTTSHRIDO1TAAR1APEX1 | |
| SCHEMBL6006682 | 0.76 | PPARA (0.56) | PNMTTSHRSMN1; SMN2TACR1 | |
| SCHEMBL6204802 | 0.76 | MEN1 (0.40) | SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL28739467 | 0.75 | TSHR (0.54) | PNMTTSHRSMN1; SMN2LMNATACR1 | |
| SCHEMBL6205215 | 0.75 | IDO1 (0.39) | PNMTTSHRIDO1TACR1 | |
| SCHEMBL6203594 | 0.74 | MAOA (0.40) | — | |
| SCHEMBL5018935 | 0.74 | PNMT (0.70) | PNMTTSHRIDO1TAAR1SIGMAR1 | |
| SCHEMBL14033316 | 0.74 | TSHR (0.57) | PNMTTSHRSMN1; SMN2LMNATACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |