Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CHAT | P28329 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16953020 | 0.86 | RELA (0.50) | RELACHRM5XDHCYP1A2CYP2C19 | |
| SCHEMBL6205403 | 0.80 | CHRM5 (0.50) | RELACHRM5CYP1A2NFE2L2FBP1 | |
| SCHEMBL6204838 | 0.80 | ALDH1A1 (0.47) | XDHMAPTEGFR | |
| SCHEMBL6205455 | 0.76 | KDM4E (0.48) | RELACHRM5CYP1A2CYP2C19MAPT | |
| SCHEMBL6203320 | 0.76 | RELA (0.47) | RELACHRM5XDHCYP1A2CYP2C19 | |
| SCHEMBL1989041 | 0.74 | CHRM5 (0.54) | RELACHRM5CYP1A2CYP2C19CHAT | |
| SCHEMBL295147 | 0.71 | CHRM5 (0.50) | RELACHRM5CYP1A2CYP2C19CHAT | |
| SCHEMBL23457217 | 0.69 | CHRM5 (0.52) | RELACHRM5CYP1A2CYP2C19CHAT | |
| SCHEMBL8702984 | 0.69 | CHRM5 (0.52) | RELACHRM5CYP1A2CYP2C19CHAT | |
| SCHEMBL1759558 | 0.69 | CHRM5 (0.52) | RELACHRM5CYP1A2CYP2C19HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506175-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003097609-A1 | N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-27 | — | — | WO | disclosed |