SCHEMBL6204838

SCHEMBL6204838

COCOC[CH]c1cccc(Br)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
XDH P47989 2/20 0.40
HSD11B1 P28845 1/20 0.39
HSD17B3 P37058 1/20 0.38
MAOA P21397 2/20 0.37
MAOB P27338 1/20 0.37
SLC6A19 Q695T7 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
MAPT P10636 2/20 0.35
POLB P06746 2/20 0.35
PKM P14618 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
CHRNA7 P36544 1/20 0.35
EGFR P00533 1/20 0.35
MAPK1 P28482 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
BACE1 P56817 1/20 0.34
PLEC Q15149 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28069963 0.83 ALDH1A1 (0.50) ALDH1A1XDHHSD11B1HSD17B3MAOA
SCHEMBL6205403 0.80 CHRM5 (0.50) TDP1
SCHEMBL6204213 0.80 RELA (0.45) XDHMAPTEGFR
SCHEMBL6205455 0.76 KDM4E (0.48) ALDH1A1MAOAMAOBSMN1; SMN2MAPT
SCHEMBL6203560 0.76 ALDH1A1 (0.46) ALDH1A1XDHHSD11B1HSD17B3MAOA
SCHEMBL16618643 0.74 ALDH1A1 (0.61) ALDH1A1HSD11B1HSD17B3MAOAMAOB
SCHEMBL2811422 0.72 SLC6A19 (0.49) ALDH1A1XDHHSD17B3MAOAMAOB
SCHEMBL2811420 0.72 SLC6A19 (0.49) ALDH1A1XDHHSD17B3MAOAMAOB
SCHEMBL18243744 0.71 ALDH1A1 (0.57) ALDH1A1HSD11B1HSD17B3MAOAMAOB
SCHEMBL511200 0.70 IDO1 (0.56) ALDH1A1MAOAMAOBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1506175-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDGF RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2005-02-16 EP disclosed
WO-2003097609-A1 N-SUBSTITUTED TRICYCLIC 3-AMINOPYRAZOLES AS PDFG RECEPTOR INHIBITORS JANSSEN PHARMACEUTICA N.V. (BE) 2003-11-27 WO disclosed