Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204310 | 0.78 | KEAP1 (0.51) | KMT2ALMNARAB9AAKR1C3AKR1C2 | |
| SCHEMBL6202161 | 0.76 | HPGD (0.56) | KMT2AKDM4EMAPK1SMN1; SMN2LMNA | |
| SCHEMBL6203398 | 0.74 | LMNA (0.60) | KMT2AKDM4EMAPK1SMN1; SMN2LMNA | |
| SCHEMBL9624375 | 0.74 | KMT2A (0.67) | KMT2AKDM4EMAPK1SMN1; SMN2ELANE | |
| SCHEMBL2201197 | 0.73 | ELANE (0.64) | KMT2AKDM4EMAPK1SMN1; SMN2LMNA | |
| SCHEMBL6205498 | 0.73 | RECQL (0.60) | KMT2ASMN1; SMN2LMNARAB9ARECQL | |
| SCHEMBL27182604 | 0.71 | ELANE (0.51) | KMT2AKDM4EMAPK1SMN1; SMN2LMNA | |
| SCHEMBL222372 | 0.71 | KCNA5 (0.61) | KMT2AKDM4ELMNAKCNA5HPGD | |
| SCHEMBL8996748 | 0.71 | KMT2A (0.65) | KMT2AKDM4EMAPK1SMN1; SMN2LMNA | |
| SCHEMBL14397868 | 0.70 | ALDH1A1 (0.61) | KMT2AKDM4EMAPK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | claimed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | claimed |
| US-20050272036-A1 | Ketones | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | US | disclosed |
| EP-1549600-A1 | KETONES | AstraZeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004011410-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | WO | disclosed |