Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.57 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | F10 | P00742 | 5/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MASP2 | O00187 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 6/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6207335 | 0.79 | PRMT5 (0.61) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| SCHEMBL1244509 | 0.79 | ALDH1A1 (0.67) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| SCHEMBL1468321 | 0.78 | PRMT5 (0.59) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL29182256 | 0.77 | ALDH1A1 (0.64) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| SCHEMBL5456054 | 0.74 | ALDH1A1 (0.67) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| Hydrochloric Acid SCHEMBL9280078 | 0.73 | PRSS1 (0.57) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| Bromide SCHEMBL11499076 | 0.73 | PRSS1 (0.57) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| Stilbamidine SCHEMBL889782 | 0.73 | PRMT1 (1.00) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| Stilbamidine SCHEMBL208655 | 0.73 | PRMT1 (1.00) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 | |
| SCHEMBL6204477 | 0.73 | F2 (0.54) | PRMT5PRMT1ALDH1A1HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539762-A2 | BICYCLIC PYRIMIDINONES AS COAGULATION CASCADE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004002406-A2 | BICYCLIC PYRIMIDINONES AS COAGULATION CASCADE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-01-08 | — | — | WO | disclosed |