Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4935654 | 0.82 | FAAH (0.47) | NPSR1GAAOPRM1OPRK1OPRL1 | |
| SCHEMBL4938511 | 0.81 | ALDH1A1 (0.40) | NPSR1GAANOTUMOPRM1OPRK1 | |
| SCHEMBL14282078 | 0.77 | FAAH (0.43) | NOTUML3MBTL3 | |
| SCHEMBL4938440 | 0.74 | FAAH (0.41) | NPSR1GAACHRM5 | |
| Trifluoromethanesulfonic Acid SCHEMBL4939925 | 0.72 | FAAH (0.43) | NOTUM | |
| SCHEMBL4933545 | 0.70 | ALDH1A1 (0.46) | GAAOPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL24233918 | 0.70 | MBTD1 (0.56) | GAACHRM5ADRA2CL3MBTL3L3MBTL1 | |
| SCHEMBL4937515 | 0.69 | ALDH1A1 (0.46) | GAANOTUMOPRM1OPRK1OPRL1 | |
| SCHEMBL12073571 | 0.69 | CHRM5 (0.48) | CHRM5ADRA2CL3MBTL3L3MBTL1 | |
| SCHEMBL4931385 | 0.69 | L3MBTL3 (0.68) | L3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556046-A1 | PHENYLPIPERIDINES AND PHENYLPYRROLIDINES AS HISTAMINE H3 RECEPTOR MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037257-A1 | PHENYLPIPERIDINES AND PHENYLPYRROLIDINES AS HISTAMINE H3 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2004-05-06 | — | — | WO | disclosed |