Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147466 | 0.83 | L3MBTL1 (0.41) | ATMMAPTALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL6204759 | 0.81 | TDP1 (0.51) | ATMTDP1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6206062 | 0.81 | ATM (0.51) | ATMTDP1MAPTL3MBTL1NPSR1 | |
| SCHEMBL6206638 | 0.78 | ATM (0.48) | ATMTDP1MAPTALDH1A1KDM4E | |
| SCHEMBL6208230 | 0.78 | ATM (0.48) | ATMTDP1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6205994 | 0.78 | TDP1 (0.48) | ATMTDP1MAPTALDH1A1NPSR1 | |
| SCHEMBL6206051 | 0.78 | TDP1 (0.48) | ATMTDP1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6251469 | 0.78 | TDP1 (0.48) | ATMTDP1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL9124237 | 0.76 | TDP1 (0.53) | ATMTDP1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6204389 | 0.76 | ATM (0.46) | ATMTDP1MAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |