Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204389 | 0.91 | ATM (0.46) | ATMTDP1MRGPRX4PARP10CXCL8 | |
| SCHEMBL6206062 | 0.81 | ATM (0.51) | ATMTDP1MRGPRX4LMNAKMT2A | |
| SCHEMBL6204759 | 0.81 | TDP1 (0.51) | ATMTDP1PPARGF2LMNA | |
| SCHEMBL6206638 | 0.81 | ATM (0.48) | ATMTDP1MRGPRX4F2LMNA | |
| SCHEMBL6206051 | 0.81 | TDP1 (0.48) | ATMTDP1F2LMNAALDH1A1 | |
| SCHEMBL6205994 | 0.81 | TDP1 (0.48) | ATMTDP1CXCL8F2LMNA | |
| SCHEMBL9124237 | 0.78 | TDP1 (0.53) | ATMTDP1F2LMNAALDH1A1 | |
| SCHEMBL6204946 | 0.78 | ATM (0.49) | ATMTDP1F2LMNAALDH1A1 | |
| SCHEMBL6206293 | 0.77 | ALDH1A1 (0.54) | ATMTDP1LMNAALDH1A1KMT2A | |
| SCHEMBL6206401 | 0.77 | ATM (0.44) | ATMTDP1MRGPRX4F2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |