Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204759 | 0.84 | TDP1 (0.51) | ATMTDP1POLBSMN1; SMN2NPC1 | |
| SCHEMBL6204946 | 0.81 | ATM (0.49) | ATMTDP1SMN1; SMN2NPC1KMT2A | |
| SCHEMBL6206051 | 0.81 | TDP1 (0.48) | ATMTDP1POLBSMN1; SMN2KMT2A | |
| SCHEMBL6208230 | 0.81 | ATM (0.48) | ATMTDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6205994 | 0.81 | TDP1 (0.48) | ATMTDP1POLBSMN1; SMN2NPC1 | |
| SCHEMBL6206638 | 0.81 | ATM (0.48) | ATMTDP1POLBSMN1; SMN2NPC1 | |
| SCHEMBL6251469 | 0.80 | TDP1 (0.48) | ATMTDP1POLBSMN1; SMN2RAB9A | |
| SCHEMBL9124237 | 0.78 | TDP1 (0.53) | ATMTDP1POLBSMN1; SMN2KMT2A | |
| SCHEMBL6204389 | 0.78 | ATM (0.46) | ATMTDP1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6206293 | 0.77 | ALDH1A1 (0.54) | ATMTDP1POLBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532128-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002977-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-01-08 | — | — | WO | disclosed |