Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204203 | 0.87 | KDM4E (0.55) | ALDH1A1NPC1TP53RAB9ABCHE | |
| SCHEMBL13381788 | 0.80 | ALDH1A1 (0.60) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL6205446 | 0.79 | SMN1; SMN2 (0.56) | ALDH1A1MEN1KMT2ANPC1TP53 | |
| SCHEMBL12504054 | 0.78 | ALDH1A1 (0.65) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL25565610 | 0.75 | ALDH1A1 (0.66) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL21550461 | 0.75 | DUSP3 (0.60) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL16122104 | 0.75 | ALDH1A1 (0.65) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL26353698 | 0.74 | ALDH1A1 (0.56) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL3979002 | 0.73 | SIGMAR1 (0.63) | ALDH1A1GAAMEN1KMT2ANPC1 | |
| SCHEMBL5796026 | 0.73 | PTGS2 (0.47) | ALDH1A1GAANPC1RAB9ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |