Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 8/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27594938 | 0.83 | DRD2 (0.48) | HSD11B1SLC18A3DRD2IDO1GRM5 | |
| SCHEMBL3546582 | 0.79 | NPC1 (0.46) | HSD11B1SLC18A3DRD2GRM5NPC1 | |
| SCHEMBL2098866 | 0.78 | HSD11B1 (0.58) | HSD11B1SLC18A3DRD2IDO1GRM5 | |
| Bicarbonate SCHEMBL1719769 | 0.77 | IDO1 (0.51) | HSD11B1SLC18A3DRD2IDO1MEN1 | |
| SCHEMBL29055984 | 0.76 | FPR2 (0.45) | — | |
| SCHEMBL16963363 | 0.75 | CCR1 (0.57) | HSD11B1SLC18A3DRD2IDO1GRM5 | |
| SCHEMBL19658652 | 0.73 | QDPR (0.62) | HSD11B1DRD2IDO1CCR1KCNH2 | |
| Carbamic Acid SCHEMBL1569088 | 0.73 | IDO1 (0.49) | HSD11B1SLC18A3DRD2IDO1MEN1 | |
| Bicarbonate SCHEMBL11118762 | 0.73 | BCL2L1 (0.50) | HSD11B1SLC18A3DRD2IDO1SMN1; SMN2 | |
| Acetic Acid SCHEMBL28980245 | 0.73 | IDO1 (0.49) | HSD11B1SLC18A3DRD2IDO1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597228-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072025-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |