SCHEMBL6205561

SCHEMBL6205561

OCCc1ccccc1Oc1cc(OCc2ccccc2)ccc1OCc1ccccc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 1/20 0.54
CYP4A11 Q02928 1/20 0.54
HTR1A P08908 2/20 0.50
DRD2 P14416 2/20 0.50
ABCB1 P08183 6/20 0.48
LTA4H P09960 1/20 0.47
EPHX2 P34913 1/20 0.47
ALOX5 P09917 1/20 0.44
BCHE P06276 2/20 0.44
LMNA P02545 2/20 0.43
ABCG2 Q9UNQ0 1/20 0.43
CYP1A2 P05177 1/20 0.43
PTGS1 P23219 1/20 0.43
SLC6A2 P23975 1/20 0.43
CYP2C19 P33261 1/20 0.43
PTGS2 P35354 1/20 0.43
SLC6A3 Q01959 1/20 0.43
HIF1A Q16665 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
MAOB P27338 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8000947 0.86 CYP4F2 (0.62) CYP4F2CYP4A11HTR1ADRD2ABCB1
SCHEMBL3268053 0.81 HTR1A (0.73) CYP4F2CYP4A11HTR1ADRD2ABCB1
SCHEMBL6205223 0.81 MAOB (0.45) HTR1ADRD2ABCB1ALOX5BCHE
SCHEMBL19612238 0.78 ALOX5 (0.56) CYP4F2CYP4A11HTR1AALOX5BCHE
SCHEMBL4953923 0.78 LTA4H (0.63) CYP4F2CYP4A11HTR1ADRD2ABCB1
SCHEMBL13412635 0.78 ALOX5 (0.63) CYP4F2CYP4A11ALOX5BCHELMNA
SCHEMBL8545383 0.77 CYP4F2 (0.54) CYP4F2CYP4A11HTR1ALTA4HEPHX2
SCHEMBL6205559 0.76 ALOX5 (0.44) ALOX5LMNACYP1A2PTGS1SLC6A2
Water SCHEMBL7910705 0.76 CYP4F2 (0.53) CYP4F2CYP4A11HTR1ALTA4HEPHX2
Water SCHEMBL7910704 0.76 CYP4F2 (0.53) CYP4F2CYP4A11HTR1ALTA4HEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1583759-A1 PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM ORION CORPORATION (FI) 2005-10-12 EP disclosed
WO-2004063191-A1 PYRIDINE DERIVATIVES USEFUL FOR INHIBITING SODIUM/CALCIUM EXCHANGE SYSTEM ORION CORPORATION (FI) 2004-07-29 WO disclosed
EP-1412343-A1 NEW COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS ORION CORPORATION (FI) 2004-04-28 EP disclosed
WO-2003006452-A1 NEW COMPOUNDS, WHICH ARE POTENT INHIBITORS OF NA+/CA2+ EXCHANGE MECHANISM AND ARE USEFUL IN THE TREATMENT OF ARRHYTHMIAS ORION CORPORATION (FI) 2003-01-23 WO disclosed