Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553062 | 0.83 | GAA (0.61) | MAPTSMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL6203873 | 0.80 | GAA (0.70) | HTTMAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL6205515 | 0.78 | GAA (0.56) | HTTMAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL1179221 | 0.74 | GABRP (0.43) | HTTMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL4054606 | 0.72 | LMNA (0.48) | HTTMAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL1682478 | 0.72 | LMNA (0.55) | HTTMAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL544885 | 0.71 | KMT2A (0.71) | HTTMAPTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL30120645 | 0.71 | KMT2A (0.71) | HTTMAPTSMN1; SMN2RAB9AMEN1 | |
| SCHEMBL12335151 | 0.71 | SMN1; SMN2 (0.54) | HTTMAPTSMN1; SMN2LMNARAB9A | |
| SCHEMBL1803890 | 0.71 | SMN1; SMN2 (0.54) | HTTMAPTSMN1; SMN2LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |