Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 4/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CDK1 | P06493 | 5/20 | 0.39 |
| ▸ | CFTR | P13569 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 3/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6202086 | 0.88 | HTR2C (0.48) | CDK5CDK5R1ATMMEN1KMT2A | |
| SCHEMBL6203247 | 0.87 | CCNE2 (0.43) | MEN1KMT2ACFTRHTR2CHTR2A | |
| SCHEMBL6205647 | 0.85 | CDK5 (0.41) | CDK5CDK5R1ATMMEN1KMT2A | |
| SCHEMBL6204174 | 0.84 | HTR2A (0.35) | CDK5CDK5R1ATMMEN1KMT2A | |
| SCHEMBL6205210 | 0.84 | HTR2A (0.35) | CDK5CDK5R1ATMMEN1KMT2A | |
| SCHEMBL6203203 | 0.82 | CDK5 (0.40) | CDK5CDK5R1ATMCDK1HTR2C | |
| SCHEMBL6204146 | 0.81 | CCNE2 (0.45) | CDK1HTR2CHTR2AKDM4ENPC1 | |
| SCHEMBL3444401 | 0.75 | MEN1 (0.48) | MEN1KMT2ACDK1KDM4EMAPT | |
| SCHEMBL6202754 | 0.75 | CDK5 (0.43) | CDK5CDK5R1MEN1KMT2ACDK1 | |
| SCHEMBL6204714 | 0.74 | SLC29A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539760-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2005-06-15 | — | — | EP | claimed |
| WO-2004018473-A2 | AZAPURINE DERIVATIVES | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2004-03-04 | — | — | WO | claimed |