SCHEMBL6205693

SCHEMBL6205693

C[C](Cc1ccncc1)C(N)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 10/20 0.45
TSHR P16473 1/20 0.43
CYP17A1 P05093 1/20 0.43
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HTT P42858 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA5A P35218 1/20 0.41
CA7 P43166 1/20 0.41
CA5B Q9Y2D0 1/20 0.41
KDM4E B2RXH2 1/20 0.39
MPO P05164 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
ADORA3 P0DMS8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14889554 0.82 LOXL2 (0.47) TSHRCYP17A1ALDH1A1LOXL2RAB9A
SCHEMBL3171335 0.79 CES1 (0.54) TSHRALDH1A1
SCHEMBL1178369 0.79 CA2 (0.58) CYP19A1CYP17A1ALDH1A1GAAMAPT
SCHEMBL48403 0.79 CYP19A1 (0.50) CYP19A1TSHRALDH1A1GAAMAPT
Iodide SCHEMBL14765165 0.77 CYP19A1 (0.49) CYP19A1TSHRALDH1A1GAAMAPT
Hydrochloric Acid SCHEMBL2673007 0.77 CA2 (0.56) CYP19A1CYP17A1ALDH1A1GAAMAPT
SCHEMBL10002451 0.76 RAB9A (0.49) ALDH1A1MAPTRAB9ASMN1; SMN2HTT
SCHEMBL3181241 0.76 TDP1 (0.47) ALDH1A1GAAMAPTRAB9ASMN1; SMN2
SCHEMBL28195356 0.76 CA1 (0.44) CYP19A1CYP17A1ALDH1A1GAAMAPT
SCHEMBL4681053 0.73 LOXL2 (0.46) CYP19A1TSHRALDH1A1GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1545523-A1 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS Astex Technology Limited (GB) 2005-06-29 EP disclosed
WO-2005002673-A1 RAF KINASE INHIBITORS ASTEX THERAPEUTICS LIMITED (GB) 2005-01-13 WO disclosed
WO-2004004720-A1 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS ASTEX TECHNOLOGY LIMITED (GB) 2004-01-15 WO disclosed