Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 13/20 | 0.39 |
| ▸ | MMP8 | P22894 | 13/20 | 0.39 |
| ▸ | MMP2 | P08253 | 12/20 | 0.39 |
| ▸ | MMP3 | P08254 | 11/20 | 0.39 |
| ▸ | MMP9 | P14780 | 11/20 | 0.39 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | MMP7 | P09237 | 4/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 4/20 | 0.36 |
| ▸ | PHGDH | O43175 | 1/20 | 0.36 |
| ▸ | MMP10 | P09238 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206525 | 0.93 | MMP13 (0.38) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL5908743 | 0.90 | MMP13 (0.41) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL6231419 | 0.88 | MMP2 (0.41) | MMP13MMP8MMP2MMP3MMP9 | |
| SCHEMBL5908559 | 0.88 | CYP3A4 (0.40) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL6206622 | 0.88 | MMP13 (0.45) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL6207034 | 0.87 | MMP13 (0.43) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL5908718 | 0.87 | CYP3A4 (0.42) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL6208098 | 0.86 | CYP3A4 (0.41) | CYP3A4CYP2C9PKMCYP2C19MMP13 | |
| SCHEMBL8316685 | 0.85 | MMP2 (0.50) | MMP13MMP8MMP2MMP3MMP9 | |
| SCHEMBL6701107 | 0.85 | CYP3A4 (0.45) | CYP3A4CYP2C9PKMCYP2C19MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1565459-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | Pharmacia Corporation (US) | 2005-08-24 | — | — | EP | disclosed |
| US-20040142979-A1 | Heteroarylsulfonylmethyl hydroxamic acids and amides and their use as protease inhibitors | PHARMACIA CORPORATION | 2004-07-22 | — | — | US | disclosed |
| WO-2004048368-A2 | HETEROARYLSULFONYLMETHYL HYDROXAMIC ACIDS AND AMIDES AND THEIR USE AS PROTEASE INHIBITORS | PHARMACIA CORPORATION (US) | 2004-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142979-A1 | Heteroarylsulfonylmethyl hydroxamic acids and amides and their use as protease inhibitors | MMP3, MMP13, MMP10 | CYP3A4 3357/4885CYP2C9 2247/4885PKM 3014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.