SCHEMBL6205792

SCHEMBL6205792

Nc1nnc(-c2ccc(F)c(F)c2Nc2ccc(Br)cc2F)o1

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 14/20 0.43
DGAT1 O75907 1/20 0.40
MAP2K2 P36507 2/20 0.35
PIM1 P11309 1/20 0.34
PIM3 Q86V86 1/20 0.34
PIM2 Q9P1W9 1/20 0.34
NOTUM Q6P988 1/20 0.34
TP53 P04637 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6206815 0.86 MAP2K1 (0.51) MAP2K1MAP2K2PIM1
SCHEMBL391367 0.81 MAP2K1 (0.59) MAP2K1MAP2K2
SCHEMBL3424014 0.80 DGAT1 (0.34) MAP2K1DGAT1MAP2K2PIM1PIM3
SCHEMBL5404404 0.79 MAP2K1 (0.36) MAP2K1DGAT1MAP2K2TP53
SCHEMBL6137572 0.78 MAP2K1 (0.40) MAP2K1MAP2K2PIM1PIM3PIM2
SCHEMBL5474880 0.78 DGAT1 (0.40) MAP2K1DGAT1MAP2K2TP53MAPT
SCHEMBL394009 0.76 MAP2K1 (0.55) MAP2K1MAP2K2
SCHEMBL6207380 0.74 TUBB4A (0.31) MAP2K1MAP2K2
SCHEMBL5406374 0.74 MAP2K1 (0.36) MAP2K1DGAT1MAP2K2TP53MAPT
SCHEMBL3972766 0.73 MAP2K1 (0.35) MAP2K1DGAT1MAP2K2NOTUMTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9707275-B2 Stable aqueous composition comprising human insulin or an analogue or derivative thereof WOCKHARDT LIMITED (IN) 2017-07-18 US claimed
US-20150265683-A1 Stable aqueous composition comprising human insulin or an analogue or derivative thereof WOCKHARDT LTD (IN) 2015-09-24 US claimed
WO-2014096985-A2 A STABLE AQUEOUS COMPOSITION COMPRISING HUMAN INSULIN OR AN ANALOGUE OR DERIVATIVE THEREOF WOCKHARDT LIMITED (IN) 2014-06-26 WO claimed
EP-1578736-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES Warner-Lambert Company LLC (US) 2005-09-28 EP claimed
US-20050004186-A1 MEK inhibiting compounds PFIZER INC 2005-01-06 US claimed
WO-2004056789-A1 MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES WARNER-LAMBERT COMPANY LLC (US) 2004-07-08 WO claimed
US-20230330727-A1 Compositions and Methods for Cleaning Contaminated Solids and Liquids FRANSSEN TODD (US) 2023-10-19 US disclosed
US-11724293-B2 Compositions and methods for cleaning contaminated solids and liquids FRANSSEN TODD (US) 2023-08-15 US disclosed
US-20210162476-A1 Compositions and Methods for Cleaning Contaminated Solids and Liquids FRANSSEN TODD (US) 2021-06-03 US disclosed
US-10906075-B2 Compositions and methods for cleaning contaminated solids and liquids FRANSSEN TODD (US) 2021-02-02 US disclosed
US-20180361444-A1 Compositions and Methods for Cleaning Contaminated Solids and Liquids FRANSSEN TODD (US) 2018-12-20 US disclosed
US-10065224-B2 Compositions and methods for cleaning contaminated solids and liquids FRANSSEN TODD (US) 2018-09-04 US disclosed
US-9707275-B2 Stable aqueous composition comprising human insulin or an analogue or derivative thereof WOCKHARDT LIMITED (IN) 2017-07-18 US disclosed
WO-1996016132-A1 CLEANING COMPOSITIONS AND METHODS OF USING THE SAME KAY CHEMICAL COMPANY (US) 1996-05-30 WO disclosed
EP-0607198-A1 PREPARATION OF IMPROVED ALKYLPOLYGLYCOSIDE SURFACTANT MIXTURES HENKEL CORPORATION (US) 1994-07-27 EP disclosed
EP-0601165-A1 AQUEOUS FLOWABLE PHENAZAQUIN COMPOSITION DOWELANCO (US) 1994-06-15 EP disclosed
WO-1993024005-A1 AQUEOUS FLOWABLE PHENAZAQUIN COMPOSITION DOWELANCO (US) 1993-12-09 WO disclosed
US-5242615-A Anionic and amphoteric surfactant compositions with reduced viscosity HENKEL CORPORATION (US) 1993-09-07 US disclosed
WO-1993007249-A1 PREPARATION OF IMPROVED ALKYLPOLYGLYCOSIDE SURFACTANT MIXTURES HENKEL CORPORATION (US) 1993-04-15 WO disclosed
WO-1991004313-A1 ANIONIC AND AMPHOTERIC SURFACTANT COMPOSITIONS WITH REDUCED VISCOSITY HENKEL CORPORATION (US) 1991-04-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050004186-A1 MEK inhibiting compounds MAPK1, MAP3K1, MAPK3 MAP2K1 46/4885DGAT1 1846/4885MAP2K2 40/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.