Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 2/20 | 0.31 |
| ▸ | TUBB | P07437 | 2/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.31 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.31 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.31 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.31 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.31 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.31 |
| ▸ | FLT1 | P17948 | 3/20 | 0.31 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.30 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6206926 | 0.81 | LMNA (0.31) | — | |
| SCHEMBL6206929 | 0.80 | CDC7 (0.45) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6207753 | 0.79 | MAP2K2 (0.34) | FLT1KDRMAP2K2MAP2K1 | |
| SCHEMBL6406191 | 0.78 | ALDH1A1 (0.38) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6205424 | 0.78 | ACHE (0.56) | — | |
| SCHEMBL6400416 | 0.77 | KDM4E (0.35) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6400419 | 0.77 | KDM4E (0.38) | — | |
| SCHEMBL6399618 | 0.76 | FLT1 (0.31) | FLT1KDRMAP2K2MAP2K1 | |
| SCHEMBL5399041 | 0.76 | MAP2K2 (0.34) | FLT1KDRMAP2K2MAP2K1 | |
| SCHEMBL6208642 | 0.76 | CYP51A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1578736-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL-PHENYLAMINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004056789-A1 | MEK INHIBITING OXA- AND THIA-DIAZOL-2-YL PHENYLAMINE DERIVATES | WARNER-LAMBERT COMPANY LLC (US) | 2004-07-08 | — | — | WO | disclosed |