Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 5/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3477919 | 0.80 | KDM4E (0.64) | — | |
| SCHEMBL6205560 | 0.79 | POLB (0.58) | POLB | |
| SCHEMBL6206709 | 0.79 | POLB (0.70) | POLB | |
| SCHEMBL6204487 | 0.77 | GABRA1 (0.51) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL6204275 | 0.76 | HTT (0.64) | GABRA1GABRB2GABRB1GABRA3POLB | |
| SCHEMBL6205914 | 0.76 | POLB (0.57) | POLB | |
| SCHEMBL6204485 | 0.76 | KDM4E (0.72) | POLB | |
| SCHEMBL6205412 | 0.75 | ALDH1A1 (0.73) | POLB | |
| SCHEMBL29518350 | 0.75 | KDM4E (0.75) | POLB | |
| SCHEMBL13267222 | 0.75 | GABRA1 (0.60) | GABRA1GABRB2GABRB1GABRA3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177177-B1 | SUBSTITUTED 4-OXO-QUINOLINE-3-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-02-23 | — | — | EP | disclosed |
| US-6413956-B1 | AGONISTS, ANTAGONISTS OR INVERSE AGONISTS AND LOCALIZATION PROBES FOR GAMMA AMINOBUTYRIC ACID BRAIN RECEPTORS; ANXIETY, DEPRESSION, DOWN SYNDROME, SLEEP AND SEIZURE DISORDERS, OVERDOSE WITH BENZODIAZEPINE DRUGS AND MEMORY ENHANCEMENT | NEUROGEN CORPORATION | 2002-07-02 | — | — | US | disclosed |