Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.47 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824230 | 0.88 | LMNA (0.54) | ALDH1A1KDM4EHPGDMAPTCYP1A2 | |
| SCHEMBL566342 | 0.83 | CSNK2A1 (0.55) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL1515873 | 0.82 | FDPS (0.67) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL2246621 | 0.82 | FDPS (0.77) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL15708974 | 0.82 | HTR7 (0.55) | ALDH1A1KDM4EMAPTCYP1A2CYP2D6 | |
| SCHEMBL27991570 | 0.82 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDMAPTFDPS | |
| SCHEMBL566481 | 0.81 | FDPS (0.53) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL3464778 | 0.81 | ALDH1A1 (0.59) | ALDH1A1KDM4EHPGDMAPTFDPS | |
| Hydrochloric Acid SCHEMBL5692390 | 0.81 | FDPS (0.74) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 | |
| SCHEMBL566676 | 0.80 | FDPS (0.51) | ALDH1A1HPGDMAPTCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |