Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.73 |
| ▸ | MAPT | P10636 | 10/20 | 0.73 |
| ▸ | NPC1 | O15118 | 10/20 | 0.73 |
| ▸ | RAB9A | P51151 | 10/20 | 0.73 |
| ▸ | TP53 | P04637 | 9/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.73 |
| ▸ | HPGD | P15428 | 7/20 | 0.73 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | XDH | P47989 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.69 |
| ▸ | GAA | P10253 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.69 |
| ▸ | RELA | Q04206 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203816 | 0.86 | MAPT (0.68) | KDM4EMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8344591 | 0.85 | LMNA (0.74) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL10016528 | 0.83 | RAB9A (1.00) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL6364028 | 0.82 | KDM4E (1.00) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL31615154 | 0.82 | MAPT (0.84) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL4925538 | 0.81 | MAPT (0.72) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL4926128 | 0.81 | TP53 (0.79) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL6071213 | 0.81 | KDM4E (0.76) | KDM4EMAPTNPC1RAB9ATP53 | |
| Hydrochloric Acid SCHEMBL6363785 | 0.81 | KDM4E (0.97) | KDM4EMAPTNPC1RAB9ATP53 | |
| SCHEMBL6205500 | 0.80 | XDH (0.71) | KDM4EMAPTNPC1RAB9ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551841-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2005-07-13 | — | — | EP | disclosed |
| WO-2004009602-A1 | PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |