Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 3/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | ADH1A | P07327 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ABL2 | P42684 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.33 |
| ▸ | THRB | P10828 | 4/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6204644 | 1.00 | MET (0.34) | METBCL2BCL2L1NR1H2NR1H3 | |
| SCHEMBL8105803 | 1.00 | MET (0.34) | METBCL2BCL2L1NR1H2NR1H3 | |
| SCHEMBL4590751 | 0.87 | ADH1A (0.36) | METADH1AKITFLT1FLT4 | |
| SCHEMBL3558952 | 0.86 | ADH1A (0.47) | METBCL2BCL2L1ADH1AKIT | |
| SCHEMBL6204135 | 0.78 | MAPT (0.38) | METNR1H2NR1H3KDM1A | |
| SCHEMBL7651865 | 0.76 | KDM1A (0.36) | NR1H2NR1H3KDM1A | |
| SCHEMBL5865471 | 0.75 | GPR119 (0.36) | NR1H2NR1H3ADAM17 | |
| SCHEMBL6205688 | 0.75 | P4HB (0.63) | — | |
| SCHEMBL18863855 | 0.73 | NR1H2 (0.35) | NR1H2NR1H3ADAM17 | |
| SCHEMBL18863857 | 0.73 | NR1H2 (0.35) | NR1H2NR1H3ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938474-B1 | CYCLOPROPYLINDOLE COMPOUNDS AND THEIR USE AS PRODRUGS | AUCKLAND UNISERVICES LTD (NZ) | 2005-11-23 | — | — | EP | disclosed |
| US-6130237-A | Condensed N-aclyindoles as antitumor agents | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-10-10 | — | — | US | disclosed |