Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | AHR | P35869 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 6/20 | 0.45 |
| ▸ | BRD4 | O60885 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HK1 | P19367 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1762488 | 0.83 | AHR (0.59) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10082608 | 0.78 | AHR (0.50) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10032 | 0.77 | NPC1 (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL29365738 | 0.77 | NPC1 (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4227502 | 0.77 | NPC1 (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL30293252 | 0.75 | NPC1 (0.96) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2138422 | 0.73 | MAPT (0.92) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL518954 | 0.73 | MAPT (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7439873 | 0.72 | MAPT (0.89) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20073842 | 0.72 | NPC1 (0.88) | NPC1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246828-B1 | BENZOSULFONES WITH CALCIUM ANTAGONIST ACTIVITY | ORTHO MCNEIL PHARM INC (US) | 2005-12-07 | — | — | EP | disclosed |
| US-6410553-B1 | CALCIUM CHANNEL BLOCKERS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-06-25 | — | — | US | disclosed |
| US-20020049326-A1 | Benzosulfones and related compositions and methods | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-04-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049326-A1 | Benzosulfones and related compositions and methods | TRPV5, TRPV1, TRPV6 | NPC1 4666/4885MAPK13 1940/4885MAPK12 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.