Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24934423 | 0.97 | FAAH (0.55) | FAAHCES1DAGLABCHEBRD4 | |
| SCHEMBL6206334 | 0.79 | MEN1 (0.46) | BCHEBRD4NPSR1MAPTGAA | |
| SCHEMBL27805184 | 0.78 | DAGLA (0.67) | FAAHCES1DAGLA | |
| SCHEMBL29025518 | 0.78 | MEN1 (0.45) | BCHEBRD4NPSR1MAPTGAA | |
| SCHEMBL1980682 | 0.78 | BCHE (0.58) | BCHEBRD4MAPTKDM4EALDH1A1 | |
| SCHEMBL30831344 | 0.77 | HDAC6 (0.55) | BCHENPSR1MAPTALDH1A1GAA | |
| SCHEMBL7049753 | 0.75 | BCHE (0.41) | BCHEBRD4MAPTKDM4EGAA | |
| SCHEMBL5422852 | 0.75 | CTSS (0.52) | CYP3A4 | |
| SCHEMBL1929771 | 0.75 | SIGMAR1 (0.52) | BCHEMAPTGAASIGMAR1CYP3A4 | |
| SCHEMBL28665621 | 0.75 | XDH (0.52) | FAAHCES1DAGLAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1515726-A1 | MORPHOLINE AND TETRAHYDROPYRAN DERIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004002491-A1 | MORPHOLINE AND TETRAHYDROPYRAN DRIVATIVES AND THEIR USE AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2004-01-08 | — | — | WO | disclosed |