Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.53 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.53 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.53 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.53 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.50 |
| ▸ | EDNRB | P24530 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5085746 | 0.88 | HNF4A (0.63) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL496484 | 0.88 | KDM4E (0.62) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7796258 | 0.85 | GPR35 (0.55) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL18377850 | 0.84 | AKR1C3 (0.55) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL8202718 | 0.81 | PRKAB2 (0.55) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL27501023 | 0.80 | GPR35 (0.56) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL8887143 | 0.80 | GAA (0.59) | KDM4EGAALMNAALDH1A1HPGD | |
| SCHEMBL10471506 | 0.78 | GPR35 (0.55) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL1515816 | 0.78 | GAA (0.62) | KDM4EGAARAB9ALMNAALDH1A1 | |
| SCHEMBL27913989 | 0.77 | WDR5 (0.58) | GPR35PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503997-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097617-A1 | CYSTEINE PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |