SCHEMBL785870

SCHEMBL785870

CSCCC(NC(=O)OC(C)(C)C)C(=O)NC1CCNCC1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSS P25774 3/20 0.56
CTSK P43235 3/20 0.56
HDAC4 P56524 1/20 0.54
HDAC1 Q13547 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
KLK5 Q9Y337 1/20 0.47
TSHR P16473 1/20 0.46
CA2 P00918 1/20 0.45
L3MBTL1 Q9Y468 2/20 0.43
LMNA P02545 2/20 0.43
KDM4E B2RXH2 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 1/20 0.41
KLK7 P49862 1/20 0.41
POLB P06746 1/20 0.41
EPHX2 P34913 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
THRB P10828 1/20 0.39
HPGD P15428 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31291788 0.89 HDAC4 (0.63) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL5218978 0.88 HDAC4 (0.68) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL6207008 0.88 HDAC4 (0.68) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL28291377 0.85 KLK5 (0.56) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL789305 0.83 CTSS (0.56) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL22962192 0.81 HDAC4 (0.50) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL8133234 0.80 HDAC4 (0.52) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL8133237 0.80 HDAC4 (0.52) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL28737415 0.77 KMT2A (0.48) CTSSCTSKHDAC4HDAC1HDAC6
SCHEMBL19734820 0.77 KMT2A (0.48) CTSSCTSKHDAC4HDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2616074-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS Array Biopharma, Inc. (US) 2013-07-24 EP disclosed
WO-2012037393-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA INC. (US) 2012-03-22 WO disclosed