Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080568 | 0.83 | KMT2A (0.48) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6207387 | 0.81 | KMT2A (0.47) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6240758 | 0.78 | RAB9A (0.49) | MEN1KMT2ANPC1RAB9AMAPK1 | |
| SCHEMBL6257230 | 0.72 | MEN1 (0.43) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL22103784 | 0.69 | RAB9A (0.76) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL22125497 | 0.68 | SMARCA2 (0.72) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL14014120 | 0.68 | RAB9A (0.80) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL20788543 | 0.68 | NPC1 (0.77) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL6079119 | 0.67 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL10078887 | 0.66 | MEN1 (1.00) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545523-A1 | 3-&-grave;(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES ASP38 MAP KINASE INHIBITORS | Astex Technology Limited (GB) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004004720-A1 | 3-`(HETERO) ARYLMETHOXY ! PYRIDINES AND THEIR ANALOGUES AS P38 MAP KINASE INHIBITORS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |