Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6079940 | 0.82 | ROCK2 (0.46) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL6257221 | 0.81 | ROCK2 (0.45) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL6207396 | 0.72 | MEN1 (0.47) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL6240758 | 0.72 | RAB9A (0.49) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL6079580 | 0.67 | KCNH2 (0.38) | MEN1KMT2AROCK1KDRFLT3 | |
| SCHEMBL22828658 | 0.64 | NPY5R (0.53) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL6080735 | 0.62 | BLM (0.55) | MEN1KMT2AALDH1A1GAARAB9A | |
| SCHEMBL6206171 | 0.62 | ELOVL1 (0.48) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL6564725 | 0.61 | RAB9A (1.00) | MEN1KMT2AALDH1A1GAANPSR1 | |
| SCHEMBL6079119 | 0.61 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1MAPTROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002673-A1 | RAF KINASE INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |