Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 13/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 13/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7859352 | 0.78 | MTNR1A (0.43) | MTNR1AMTNR1BMCHR1HTR2CKDM4E | |
| SCHEMBL15228572 | 0.77 | SLC40A1 (0.38) | ALDH1A1 | |
| SCHEMBL4958755 | 0.75 | POLB (0.44) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL22559305 | 0.75 | MTNR1A (0.44) | MTNR1AMTNR1BMCHR1 | |
| SCHEMBL30867647 | 0.75 | MTNR1A (0.44) | MTNR1AMTNR1BMCHR1 | |
| SCHEMBL15228835 | 0.73 | PARP1 (0.48) | NPC1RAB9AKDM4EALDH1A1MAPT | |
| SCHEMBL4489968 | 0.73 | MTNR1A (0.44) | MTNR1AMTNR1BMCHR1HTR2CPRMT5 | |
| SCHEMBL1711985 | 0.73 | MTNR1A (0.50) | MTNR1AMTNR1BHTR2CALDH1A1POLB | |
| SCHEMBL21495104 | 0.73 | CYP3A4 (0.38) | — | |
| SCHEMBL15228400 | 0.73 | PSMD14 (0.47) | KDM4EALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583537-A3 | PIPERIDINE COMPOUNDS AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2005-12-14 | — | — | EP | disclosed |
| EP-1583537-A2 | PIPERIDINE COMPOUNDS AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004002490-A2 | PIPERIDINE COMPOUNDS AS ANTIBACTERIALS | GLAXO GROUP LIMITED (GB) | 2004-01-08 | — | — | WO | disclosed |