Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25273694 | 0.90 | KDR (0.41) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL31391902 | 0.74 | KDR (0.36) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL17645602 | 0.70 | HTR6 (0.43) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL19153475 | 0.67 | DRD2 (0.41) | NNMT | |
| SCHEMBL17661774 | 0.67 | KDR (0.41) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL8189436 | 0.66 | DGAT1 (0.39) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL8186102 | 0.66 | HTR2C (0.38) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL8191394 | 0.65 | DGAT1 (0.41) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL8176685 | 0.65 | HTR2C (0.36) | KDRHTR2CHTR2AHTR2BDGAT1 | |
| SCHEMBL18237385 | 0.63 | DRD4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1238979-B1 | FUSED HETEROTRICYCLIC COMPOUNDS, PROCESS FOR PREPARING THE COMPOUNDS AND DRUGS CONTAINING THE SAME | EISAI CO LTD (JP) | 2005-03-02 | — | — | EP | disclosed |